Affiliation:
1. School of Biosciences, University of Exeter, Devon, United Kingdom
Abstract
ABSTRACT
Bacterial lipoproteins are a set of membrane proteins with many different functions. Due to this broad-ranging functionality, these proteins have a considerable significance in many phenomena, from cellular physiology through cell division and virulence. Here we give a general overview of lipoprotein biogenesis and highlight examples of the roles of lipoproteins in bacterial disease caused by a selection of medically relevant Gram-negative and Gram-positive pathogens:
Mycobacterium tuberculosis
,
Streptococcus pneumoniae
,
Borrelia burgdorferi
, and
Neisseria meningitidis
. Lipoproteins have been shown to play key roles in adhesion to host cells, modulation of inflammatory processes, and translocation of virulence factors into host cells. As such, a number of lipoproteins have been shown to be potential vaccines. This review provides a summary of some of the reported roles of lipoproteins and of how this knowledge has been exploited in some cases for the generation of novel countermeasures to bacterial diseases.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference206 articles.
1. GNA33 of
Neisseria meningitidis
Is a Lipoprotein Required for Cell Separation, Membrane Architecture, and Virulence
2. Alloing, G., P. de Philip, and J. P. Claverys. 1994. Three highly homologous membrane-bound lipoproteins participate in oligopeptide transport by the Ami system of the gram-positive Streptococcus pneumoniae. J. Mol. Biol. 241:44-58.
3. Identification and Characterization of a Determinant (
eep
) on the
Enterococcus faecalis
Chromosome That Is Involved in Production of the Peptide Sex Pheromone cAD1
4. Cloning of the Streptococcus gordonii PK488 gene, encoding an adhesin which mediates coaggregation with Actinomyces naeslundii PK606
5. Arenas, J., A. Abel, S. Sanchez, B. Alcala, M. T. Criado, and C. M. Ferreiros. 2006. Locus NMB0035 codes for a 47-kDa surface-accessible conserved antigen in Neisseria. Int. Microbiol. 9:273-280.
Cited by
361 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献