Affiliation:
1. Quotient Bioresearch Ltd., Fordham, United Kingdom
2. Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy
Abstract
ABSTRACT
The macrolide efflux mechanism of resistance,
mef
, was characterized in community-acquired respiratory tract infections with
Streptococcus pyogenes.
Fifty-four (4.6%) M phenotype isolates were screen tested as negative for
mef
(A). Of these 54 isolates, 5 (0.4%), 27 (2.3%), and 1 (0.1%) were considered to be
mef
(I) positive, a novel mosaic variant of
mef
, or a novel subclass of
mef
, respectively. This study shows (i) the definitive presence of
mef
(E) in
S. pyogenes
and its global distribution, (ii) the presence of a mosaic variant of
mef
composed of
mef
(A) and
mef
(E), (iii) the previously undescribed presence of
mef
(I) in
S. pyogenes
, and (iv) the presence of a novel subclass of
mef
in
S. pyogenes
.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
14 articles.
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