Author:
Bryant Kendall A.,Van Schooneveld Trevor C.,Thapa Ishwor,Bastola Dhundy,Williams Laurina O.,Safranek Thomas J.,Hinrichs Steven H.,Rupp Mark E.,Fey Paul D.
Abstract
ABSTRACTWe describe the transfer ofblaKPC-4fromEnterobacter cloacaetoSerratia marcescensin a single patient. DNA sequencing revealed that KPC-4 was encoded on an IncL/M plasmid, pNE1280, closely related to pCTX-M360. Further analysis found that KPC-4 was encoded within a novel Tn4401element (Tn4401f) containing a truncatedtnpAand lackingtnpR, ISKpn7left, and Tn4401IRL-1, which are conserved in other Tn4401transposons. This study highlights the continued evolution of Tn4401transposons and movement to multiple plasmid backbones that results in acquisition by multiple species of Gram-negative bacilli.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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