Evaluation of Susceptibility Testing Methods for Aztreonam and Ceftazidime-Avibactam Combination Therapy on Extensively Drug-Resistant Gram-Negative Organisms-Reference-Cited by-同舟云学术

Evaluation of Susceptibility Testing Methods for Aztreonam and Ceftazidime-Avibactam Combination Therapy on Extensively Drug-Resistant Gram-Negative Organisms

Published:2021-10-18 Issue:11 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Khan Ayesha¹^ORCID,Erickson Samuel G.¹,Pettaway Cedric¹,Arias Cesar A.¹²,Miller William R.¹^ORCID,Bhatti Micah M.³^ORCID

Affiliation:

1. Center for Antimicrobial Resistance and Microbial Genomics, Division of Infectious Diseases, UTHealth, McGovern Medical School, UTHealth, Houston, Texas, USA

2. Center for Infectious Diseases, UTHealth School of Public Health, Houston, Texas, USA

3. Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Abstract

Carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CR-PA) producing metallo-β-lactamases (MBLs) cause severe nosocomial infections with no defined treatment. The combination of aztreonam (ATM) with ceftazidime-avibactam (CZA) is a potential therapeutic option, but there is no approved, feasible testing method for use in clinical laboratories to assess the activity of two antimicrobials in combination.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00846-21

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