Antecedent Carbapenem Exposure as a Risk Factor for Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae and Carbapenemase-Producing Enterobacteriaceae-Reference-Cited by-同舟云学术

Antecedent Carbapenem Exposure as a Risk Factor for Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae and Carbapenemase-Producing Enterobacteriaceae

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Marimuthu Kalisvar¹²³,Ng Oon Tek¹²⁴,Cherng Benjamin Pei Zhi³⁵⁶,Fong Raymond Kok Choon⁷,Pada Surinder Kaur⁸,De Partha Pratim⁹,Ooi Say Tat¹⁰,Smitasin Nares³¹¹,Thoon Koh Cheng³⁴⁶¹²,Krishnan Prabha Unny⁴⁹¹³,Ang Michelle Lay Teng¹³,Chan Douglas Su Gin¹⁴,Kwa Andrea Lay Hoon⁶¹⁵,Deepak Rama Narayana¹⁶,Chan Yu Kit¹²,Chan Yvonne Fu Zi⁵,Huan Xiaowei²,Zaw Linn Kyaw²,Tee Nancy Wen Sim¹⁷,Tan Thean Yen¹⁸,Koh Tse Hsien⁶¹⁹,Lin Raymond Tzer Pin¹³¹⁷²⁰,Hsu Li Yang¹²²¹,Sengupta Sharmila²,Paterson David L.²²,Perencevich Eli²³,Harbarth Stephan²⁴,Teo Jeanette¹⁷^ORCID,Venkatachalam Indumathi⁵,

Affiliation:

1. Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore

2. National Centre for Infectious Diseases, Singapore

3. Yong Loo Lin School of Medicine, National University of Singapore, Singapore

4. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

5. Department of Infectious Diseases, Singapore General Hospital, Singapore

6. DUKE-NUS Medical School, National University of Singapore, Singapore

7. Department of Infectious Diseases, Changi General Hospital, Singapore

8. Department of Infectious Diseases, Ng Teng Fong General Hospital, Singapore

9. Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore

10. Division of Infectious Diseases, Department of General Medicine, Khoo Teck Puat Hospital, Singapore

11. Division of Infectious Disease, University Medicine Cluster, National University Hospital, Singapore

12. Infectious Disease Service, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore

13. National Public Health Laboratory, National Centre for Infectious Diseases, Singapore

14. Department of Laboratory Medicine, Ng Teng Fong General Hospital, Singapore

15. Department of Pharmacy, Singapore General Hospital, Singapore

16. Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore

17. Department of Laboratory Medicine, National University Hospital, Singapore

18. Department of Laboratory Medicine, Changi General Hospital, Singapore

19. Department of Microbiology, Singapore General Hospital, Singapore

20. Department of Microbiology and Immunology, National University of Singapore, Singapore

21. Saw Swee Hock School Of Public Health, National University of Singapore, Singapore

22. Centre for Clinical Research, University of Queensland, Queensland, Australia

23. Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

24. Infection Control Program, WHO Collaborating Center for Patient Safety, Geneva University Hospitals, Geneva, Switzerland

Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) can be mechanistically classified into carbapenemase-producing Enterobacteriaceae (CPE) and non-carbapenemase-producing carbapenem nonsusceptible Enterobacteriaceae (NCPCRE). We sought to investigate the effect of antecedent carbapenem exposure as a risk factor for NCPCRE versus CPE. Among all patients with CRE colonization and infection, we conducted a case-control study comparing patients with NCPCRE (cases) and patients with CPE (controls).

Funder

MOH | National Medical Research Council

Ministry of Education - Singapore

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00845-19

Reference24 articles.

1. A systematic review of the epidemiology of carbapenem-resistant Enterobacteriaceae in the United States

2. Infection control implications of heterogeneous resistance mechanisms in carbapenem-resistant Enterobacteriaceae (CRE)