Antischistosomal Activity of Hexadecyloxypropyl Cyclic 9-( S )-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine and Other Alkoxyalkyl Esters of Acyclic Nucleoside Phosphonates Assessed by Schistosome Worm Killing In Vitro-Reference-Cited by-同舟云学术

Antischistosomal Activity of Hexadecyloxypropyl Cyclic 9-( S )-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine and Other Alkoxyalkyl Esters of Acyclic Nucleoside Phosphonates Assessed by Schistosome Worm Killing In Vitro

Published:2009-12 Issue:12 Volume:53 Page:5284-5287
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Botros Sanaa S.¹,William Samia²,Beadle James R.³,Valiaeva Nadejda³,Hostetler Karl Y.³

Affiliation:

1. Departments of Pharmacology

2. Parasitology, Theodor Bilharz Research Institute, Warrak el-Hadar, Imbaba, P.O. Box 30, Giza 12411, Egypt

3. San Diego Veterans Medical Research Foundation and Department of Medicine, Division of Infectious Disease, University of California, San Diego, La Jolla, California 92093

Abstract

ABSTRACT 9-( S )-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine [( S )-HPMPA] has been reported to have antischistosomal activity. Ether lipid esters of ( S )-HPMPA and cidofovir (CDV) have greatly increased activities in antiviral assays and in lethal animal models of poxvirus diseases. To see if ether lipid esters of CDV and ( S )-HPMPA enhance antischistosomal activity, we tested their alkoxyalkyl esters using Schistosoma mansoni worm killing in vitro. Hexadecyloxypropyl (HDP)-cyclic-( S )-HPMPA and HDP-cyclic-CDV exhibited significant in vitro antischistosomal activities and may offer promise alone or in combination with praziquantel.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00840-09

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