Reassortment of Simian Virus 40 DNA During Serial Undiluted Passage-Reference-Cited by-同舟云学术

Reassortment of Simian Virus 40 DNA During Serial Undiluted Passage

Published:1973-10 Issue:4 Volume:12 Page:748-757
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Martin Malcolm A.¹,Gelb Lawrence D.¹,Fareed George C.¹,Milstien Julie B.¹

Affiliation:

1. Laboratory of Biology of Viruses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Alterations occur in the supercoiled form of viral DNA after the serial undiluted passaging of simian virus (SV) 40. We have identified a portion of the viral genome which is amplified during this process. These SV40 DNA sequences represent about 30% of the viral genetic information and are present in a reiterated form in twisted circular molecules prepared from purified virions. In addition, reiterated and unique green monkey DNA sequences are incorporated into supercoiled viral DNA. The cellular DNA appears to be inserted at numerous locations in the DNA I molecules.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.12.4.748-757.1973

Reference16 articles.

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2. Repeated sequences in DNA;Britten R. J.;Science,1968

3. In Yearb;Britten R. J.;Carnegie Inst.,1970

4. A membrane-filter technique for the detection of complementary DNA;Denhardt D. T.;Biochem. Biophys. Res. Commun.,1966

5. Quantitation of simian virus 40 sequences in African green monkey, mouse and virus-transformed cell genomes;Gelb L. D.;J. Mol. Biol.,1971

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