Affiliation:
1. Departments of Medical Microbiology, Microbiology, and Pharmaceutical Biochemistry, University of Uppsala, Uppsala, Sweden
Abstract
Staphylococcus aureus
Cowan I was exposed to nitrosoguanidine or ethyl-methanesulfonate, and survivors were screened on nutrient agar plates containing rabbit anti-protein A serum for loss of protein A production. More than half of all protein A-deficient mutants also lacked nuclease, coagulase, alpha hemolysin, fibrinolysin, mannitol utilization, and the phage-type pattern. Mutants with a spectrum of these properties were also isolated. Induced or spontaneous reversions of the mutants were observed. The properties of the protein A-deficient mutants suggest that synthesis or release (or both) of a number of extracellular products of
S. aureus
is controlled by a common regulatory mechanism.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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