High-level resistance to trimethoprim in Shigella sonnei associated with plasmid-encoded dihydrofolate reductase type I

Author:

Delgado R1,Otero J R1

Affiliation:

1. Servicio de Microbiología, Hospital Primero de Octubre, Madrid, Spain.

Abstract

By DNA hybridization, the gene encoding dihydrofolate reductase type I was found in 58 of 59 highly trimethoprim-resistant clinical isolates of Shigella sonnei obtained from 1981 through 1987 in Madrid, Spain. No strain harbored the type II gene. In selected strains, the type I gene was demonstrated to be in a plasmid.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference16 articles.

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4. Trimethoprim resistant Shigella and enterotoxigenic Escherichia coli strains in children;Chatkaeomorakot A.;Thailand. Pediatr. Infect. Dis. J.,1987

5. Combined agar diffusion and replica plating techniques in the study of antibacterial substances;Elek S. D.;J. Clin. Pathol.,1954

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