Affiliation:
1. Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, The Netherlands.
Abstract
The effect of lipid composition on the intracellular antibacterial activity of ampicillin-containing liposomes was studied in vitro by using mouse peritoneal macrophages infected with Listeria monocytogenes. Two types of liposomes, a fluid type, consisting of cholesterol-phosphatidylcholine-phosphatidylserine (5:4:1), and a solid type, consisting of cholesterol-distearoylphosphatidylcholine-dipalmitoylphosphatidylglyc ero l (10:10:1), were used. Although the cellular uptake of both types of liposomes was similar, they differed with respect to the rate of intracellular degradation. A correlation was found between the relatively slow degradation of the solid liposomes and a delayed intracellular release of the encapsulated ampicillin, as reflected in absent or delayed intracellular killing of L. monocytogenes.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference14 articles.
1. Free versus liposomeentrapped ampicillin in treatment of infection due to Listeria monocytogenes in normal and athymic (nude) mice;Bakker-Woudenberg I. A. J. M.;J. Infect. Dis.,1985
2. Effect of liposome-entrapped ampicillin on survival of Listeria monocytogenes in murine peritoneal macrophages;Bakker-Woudenberg I. A. J. M.;Antimicrob. Agents Chemother.,1986
3. Antimicrobial chemotherapy directed by liposomes;Bakker-Woudenberg I. A. J. M.;J. Antimicrob. Chemother.,1986
4. Bakker-Woudenberg I. A. J. M. F. H. Roerdink and G. L. Scherphof. 1988. Drug targeting in antimicrobial chemotherapy by means of liposomes p. 325-336. In G. Gregoriadis (ed.) Liposomes as drug carriers: trends and progress. John Wiley & Sons Ltd. Chichester England.
5. Killing of intraphagocytic Staphylococcus aureus by dihydrostreptomycin entrapped within liposomes;Bonventre P. F.;Antimicrob. Agents Chemother.,1978
Cited by
22 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献