Pharmacokinetics of LY163892 in infants and children

Author:

Nelson J D1,Shelton S1,Kusmiesz H1

Affiliation:

1. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063.

Abstract

Two dosages (7.5 and 15 mg/kg of body weight) of LY163892 were given to infants and children, and five plasma specimens were collected for antibiotic assay during the ensuing 4 h. Peak concentrations of 12.6 and 18.7 micrograms/ml occurred at 45 min. The mean half-lives were 0.85 and 0.78 h, and the mean areas under the curve were 24.4 and 38.0 micrograms.h/ml.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference5 articles.

1. Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem LY163892;Jones R. N.;Eur. J. Clin. Microbiol.,1987

2. In vitro activities of LY163892, cefaclor, and cefuroxime;Knapp C. C.;Antimicrob. Agents Chemother.,1988

3. Pharmacokinetics of cefaclor in infants and children;McCracken G. H.;J. Antimicrob. Chemother.,1978

4. Metzer L. M. 1969. NONLIN: a computer program for parametric estimation of nonlinear situations. Technical report no. 7392/ 69/7272/005. The Upjohn Co. Kalamazoo Mich.

5. In vitro susceptibilities of common pediatric pathogens to LY163892;Shelton S.;Antimicrob. Agents Chemother.,1988

Cited by 20 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3