Affiliation:
1. Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Abstract
ABSTRACT
The largest family of solute transporters (major facilitator superfamily [MFS]) includes proton-motive-force-driven secondary transporters. Several characterized MFS transporters utilize essential acidic residues that play a critical role in the energy-coupling mechanism during transport. Surprisingly, we show here that no single acidic residue plays an irreplaceable role in the
Escherichia coli
secondary multidrug transporter MdfA.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference31 articles.
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