Human Monocyte Receptors Involved in Tumor Necrosis Factor Responses to Group B Streptococcal Products-Reference-Cited by-同舟云学术

Human Monocyte Receptors Involved in Tumor Necrosis Factor Responses to Group B Streptococcal Products

Published:2000-02 Issue:2 Volume:68 Page:994-998
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Cuzzola Maria¹,Mancuso Giuseppe¹,Beninati Concetta¹,Biondo Carmelo¹,von Hunolstein Christina²,Orefici Graziella²,Espevik Terje³,Flo Trude H.³,Teti Giuseppe¹

Affiliation:

1. Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università degli Studi di Messina, I-98125 Messina,1 and

2. Laboratorio di Micologia e Batteriologia, Istituto Superiore di Sanità, I-00143 Rome,2 Italy, and

3. Institute for Cancer Research, University of Trondheim, 7489 Trondheim, Norway3

Abstract

ABSTRACT Several group B streptococcal products have been previously found to stimulate human monocytes to produce tumor necrosis factor alpha. In order to identify the receptors involved in these responses, monocytes were stimulated with purified group- or type-specific carbohydrates or lipoteichoic acid in the presence of anti-receptor monoclonal antibodies, soluble CD14, or lipopolysaccharide-binding protein. Results indicate that CD14 plays an important role in tumor necrosis factor alpha responses to all of the stimuli tested. Moreover, both CD14 and complement receptor type 3 may be involved in responses to the group-antigen.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.2.994-998.2000

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