Candida albicans -Derived β-1,2-Linked Mannooligosaccharides Induce Desensitization of Macrophages-Reference-Cited by-同舟云学术

Candida albicans -Derived β-1,2-Linked Mannooligosaccharides Induce Desensitization of Macrophages

Published:2000-02 Issue:2 Volume:68 Page:965-968
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Jouault Thierry¹,Fradin Chantal¹,Trinel Pierre-André¹,Poulain Daniel¹

Affiliation:

1. Laboratoire de Mycologie Fondamentale et Appliquée, INSERM E9915, Université de Lille II, Faculté de Médecine H. Warembourg, Lille, France

Abstract

ABSTRACT Candida albicans β-1,2-oligomannosides stimulate macrophage tumor necrosis factor alpha (TNF-α) but not NO release. This stimulation desensitized macrophages by altering β-1,2-oligomannoside-dependent TNF-α production and lipopolysaccharide-dependent TNF-α and NO secretion. Desensitization was not related to tyrosine phosphorylation signal transduction but was transferred by culture supernatants in which arachidonic acid derivatives were evidenced.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.2.965-968.2000

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