Monoclonal Antibodies with Neutralizing Activity and Fc-Effector Functions against the Machupo Virus Glycoprotein-Reference-Cited by-同舟云学术

Monoclonal Antibodies with Neutralizing Activity and Fc-Effector Functions against the Machupo Virus Glycoprotein

Published:2020-02-14 Issue:5 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Amanat Fatima¹²,Duehr James¹²,Huang Cheng³,Paessler Slobodan³,Tan Gene S.⁴⁵,Krammer Florian²^ORCID

Affiliation:

1. Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA

2. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

3. Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA

4. Infectious Diseases, The J. Craig Venter Institute, La Jolla, California, USA

5. Division of Infectious Disease, Department of Medicine, University of California San Diego, La Jolla, California, USA

Abstract

MACV infections are a significant public health concern and lead to high case fatality rates. No specific treatment or vaccine for MACV infections exist. However, cases of Junin virus infection, a related virus, can be treated with convalescent-phase serum. This indicates that a MAb-based therapy for MACV could be effective. Here, we describe several MAbs that neutralize MACV and could be used for this purpose.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01741-19

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