Droplet Digital PCR-Based Detection of Clarithromycin Resistance in Helicobacter pylori Isolates Reveals Frequent Heteroresistance-Reference-Cited by-同舟云学术

Droplet Digital PCR-Based Detection of Clarithromycin Resistance in Helicobacter pylori Isolates Reveals Frequent Heteroresistance

Published:2018-09 Issue:9 Volume:56 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Sun Lu¹^ORCID,Talarico Sarah²,Yao Lena³⁴,He Lihua¹,Self Steve³⁴,You Yuanhai¹,Zhang Huifang¹,Zhang Yiyao¹,Guo Yongjun⁵,Liu Guodong⁶,Salama Nina R.²⁴^ORCID,Zhang Jianzhong¹^ORCID

Affiliation:

1. State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China

2. Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

3. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

4. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

5. Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

6. Beijing Centers for Disease Prevention and Control, Beijing, China

Abstract

Chronic infection with Helicobacter pylori causes peptic ulcers and stomach cancer in a subset of infected individuals. While standard eradication therapy includes multiple antibiotics, treatment failure due to resistance is an increasing clinical problem.

Funder

China Mega Project for Infectious Disease

National Technology R&D in the 12th Five Year Plan of China

State Key Laboratory of Infectious Disease Prevention and Control

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00019-18

Reference26 articles.

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4. New Site of Modification of 23S rRNA Associated with Clarithromycin Resistance of Helicobacter pylori Clinical Isolates

5. Gene mutations of 23S rRNA associated with clarithromycin resistance in Helicobacter pylori strains isolated from Korean patients;Kim JM;J Microbiol Biotechnol,2008

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