Mycobacterium bovis BCG Given at Birth Followed by Inactivated Respiratory Syncytial Virus Vaccine Prevents Vaccine-Enhanced Disease by Promoting Trained Macrophages and Resident Memory T Cells-Reference-Cited by-同舟云学术

Mycobacterium bovis BCG Given at Birth Followed by Inactivated Respiratory Syncytial Virus Vaccine Prevents Vaccine-Enhanced Disease by Promoting Trained Macrophages and Resident Memory T Cells

Published:2023-03-30 Issue:3 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wang Yang¹,Ge Fei¹,Wang Junhai¹,Li Hanglin¹,Zheng Boyang¹²,Li Wenjian¹³,Chen Shunyan¹,Zheng Xiaoqing¹³,Deng Yuqing¹³,Wang Yueling¹,Zeng Ruihong¹³^ORCID

Affiliation:

1. Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China

2. The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

3. Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Shijiazhuang, Hebei, China

Abstract

RSV is the leading cause of severe lower respiratory tract infection of infants. ERD, characterized by Th2-biased responses, inflammation, and poor immune memory, has been an obstacle to the development of safe and effective killed RSV vaccines.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hebei Province

Science and Technology Project of Hebei Education Department

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01764-22

Reference50 articles.

1. Respiratory Syncytial Virus–Associated Mortality in Hospitalized Infants and Young Children