Lymph-Node-Based CD3 <sup>+</sup> CD20 <sup>+</sup> Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection-Reference-Cited by-同舟云学术

Lymph-Node-Based CD3 ⁺ CD20 ⁺ Cells Emerge from Membrane Exchange between T Follicular Helper Cells and B Cells and Increase Their Frequency following Simian Immunodeficiency Virus Infection

Published:2023-06-29 Issue:6 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Samer Sadia¹,Chowdhury Ankita¹,Wiche Salinas Tomas Raul¹,Estrada Perla M. Del Rio²,Reuter Morgan³,Tharp Gregory⁴,Bosinger Steven¹⁴⁵,Cervasi Barbara¹,Auger James¹,Gill Kiran¹,Ablanedo-Terrazas Yuria⁶,Reyes-Teran Gustavo⁷,Estes Jacob D.⁸,Betts Michael R.³,Silvestri Guido¹⁵,Paiardini Mirko¹⁵^ORCID

Affiliation:

1. Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA

2. Centro de Investigacion en Enfermedades Infecciosas, Mexico City, Mexico

3. Department of Microbiology and Center for AIDS Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

4. Emory NHP Genomics Core Laboratory, Emory University, Atlanta, Georgia, USA

5. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

6. Práctica Médica Grupal en Otorrinolaringología, Centro Médico ABC Santa Fe, Mexico City, Mexico

7. Comisión Coordinadora de los Institutos Nacionales de Salud y Hospitales de Alta Especialidad, Mexico City, Mexico

8. AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, USA

Abstract

The HIV reservoir is largely composed of latently infected memory CD4 + T cells that persist during antiretroviral therapy and constitute a major barrier toward HIV eradication. In particular, CD4 + T follicular helper cells have been demonstrated as key targets for viral replication and persistence under ART.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01760-22

Reference40 articles.

1. Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

2. Lymphoid organs function as major reservoirs for human immunodeficiency virus.

3. T Follicular Helper Cell Differentiation, Function, and Roles in Disease

4. Memory T Follicular Helper CD4 T Cells

5. PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals

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