Affiliation:
1. Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, Illinois, USA
Abstract
Oncolytic herpes simplex virus 1 is a promising agent for cancer immunotherapy. Due to a complex virus-host interaction, less is clear about what viral signature(s) constitutes a potent oncolytic backbone. Through molecular or genetic dissection, we showed that selective editing of the γ
1
34.5 gene enables viral replication in malignant cells, activation of transcription factor IRF3, and subsequent induction of type I IFN. This translates into profoundly reduced primary tumor growth and metastasis burden in an aggressive breast carcinoma model
in vivo
. Our work reveals a distinct oncolytic platform that is amendable for further development.
Funder
HHS | NIH | NIH Office of the Director
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
10 articles.
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