Antibody Screening System Using a Herpes Simplex Virus (HSV)-Based Probe To Identify a Novel Target for Receptor-Retargeted Oncolytic HSVs-Reference-Cited by-同舟云学术

Antibody Screening System Using a Herpes Simplex Virus (HSV)-Based Probe To Identify a Novel Target for Receptor-Retargeted Oncolytic HSVs

Published:2021-04-12 Issue:9 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ikeda Hitomi¹²³⁴,Uchida Hiroaki¹²³^ORCID,Okubo Yu²³,Shibata Tomoko¹²³,Sasaki Yasuhiko¹²,Suzuki Takuma¹²³,Hamada-Uematsu Mika¹²,Hamasaki Ryota¹²⁵,Okuda Kosaku¹⁵,Yamaguchi Miki⁶,Kojima Masaki⁷,Tanaka Masato⁴,Hamada Hirofumi³⁶,Tahara Hideaki¹²⁸

Affiliation:

1. Project Division of Cancer Biomolecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

2. Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

3. Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

4. Immune Regulation Laboratory, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

5. Ono Pharmaceutical Co., Ltd., Osaka, Japan

6. Department of Molecular Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Hokkaido, Japan

7. Bioinformatics Laboratory, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan

8. Department of Cancer Drug Discovery and Development, Osaka International Cancer Institute, Osaka, Japan

Abstract

The tropism of the cellular entry of HSV is dependent on the binding of the envelope gD to one of its authentic receptors. This can be fully retargeted to other receptors by inserting scFvs into gD with appropriate modifications.

Funder

Daiwa Securities Health Foundation

Ministry of Education, Culture, Sports, Science and Technology

Mochida Memorial Foundation for Medical and Pharmaceutical Research

Ono Pharmaceutical

Sumitomo Foundation

Takeda Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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