Lactic Acid Polymers as Biodegradable Carriers of Fluoroquinolones: An In Vitro Study-Reference-Cited by-同舟云学术

Lactic Acid Polymers as Biodegradable Carriers of Fluoroquinolones: An In Vitro Study

Published:1999-03 Issue:3 Volume:43 Page:714-716
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kanellakopoulou Kyriaki¹,Kolia Maria²,Anastassiadis Antonios³,Korakis Themistoklis³,Giamarellos-Bourboulis Evangelos J.²,Andreopoulos Andreas⁴,Dounis Eleftherios³,Giamarellou Helen¹

Affiliation:

1. Fourth Department of Internal Medicine, Athens Medical School, Sismanoglion General Hospital,1

2. First Department of Propedeutic Medicine, Athens Medical School,2and

3. Department of Orthopaedics,3 Laiko General Hospital, and

4. Department of Chemical Engineering, Athens Polytechnique School,4 Athens, Greece

Abstract

ABSTRACT A biodegradable polymer of dl -dilactide that facilitates release of ciprofloxacin or pefloxacin at levels exceeding MICs for the causative microorganisms of chronic osteomyelitis is described. Duration and peak of release were found to depend on the molecular weight of the polymer. Its characteristics make it promising for treating chronic bone infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.3.714

Reference15 articles.

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4. Dounis E. Rifiotis C. Kanellakopoulou K. Andreopoulos A. Papakostas K. Giamarellou H. Study of the in vivo pefloxacin release from lactic acid polymer a biodegradable system of controlled drug release abstr. 33 Program and abstracts of the 14th Annual Meeting of the European Bone and Joint Infection Society Copenhagen Denmark 1995 35

5. In vitro activity of fluoroquinolones against Gram-positive bacteria.;Eliopoulos G. M.;Drugs,1995

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