Fosfomycin Alters Lipopolysaccharide-Induced Inflammatory Cytokine Production in Mice-Reference-Cited by-同舟云学术

Fosfomycin Alters Lipopolysaccharide-Induced Inflammatory Cytokine Production in Mice

Published:1999-03 Issue:3 Volume:43 Page:697-698
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Matsumoto Tetsuya¹,Tateda Kazuhiro¹,Miyazaki Shuichi¹,Furuya Nobuhiko¹,Ohno Akira¹,Ishii Yoshikazu¹,Hirakata Yoichi²,Yamaguchi Keizo¹

Affiliation:

1. Department of Microbiology, Toho University School of Medicine, Omori-Nishi, Ota-ku, Tokyo,1and

2. Department of Laboratory Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki,2 Japan

Abstract

ABSTRACT To determine the mechanisms of immunomodulating action of fosfomycin (FOF), we examined its effect on the production of inflammatory cytokines in mice injected with lipopolysaccharide (LPS). Treatment with FOF significantly lowered the peak serum levels of tumor necrosis factor alpha and interleukin-1β, indicating that FOF alters inflammatory cytokine production after LPS stimulation.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.3.697

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