Author:
Li Wei,Sakamuri Rama M.,Lyons Danielle E.,Orcullo Florenda M.,Shinde Vidyagouri,Pena Edred Lao Dela,Maghanoy Armi A.,Mallari Irene B.,Tan Esterlina V.,Nath Indira,Brennan Patrick J.,Balagon Marivic,Vissa Varalakshmi
Abstract
ABSTRACTDrug resistance surveillance identified six untreated leprosy patients in the Philippines withMycobacterium lepraefolP1mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked byM. lepraevariable-number tandem repeat (VNTR) strain types. In India,folP1mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target generpoB. These findings indicate that dapsone resistance is being transmitted.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
9 articles.
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