Affiliation:
1. Departments of Medicine
2. Microbiology and Immunology, Vanderbilt University School of Medicine
3. Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee
Abstract
SUMMARY
Helicobacter pylori
is a gram-negative bacterium that persistently colonizes more than half of the global human population. In order to successfully colonize the human stomach,
H. pylori
must initially overcome multiple innate host defenses. Remarkably,
H. pylori
can persistently colonize the stomach for decades or an entire lifetime despite development of an acquired immune response. This review focuses on the immune response to
H. pylori
and the mechanisms by which
H. pylori
resists immune clearance. Three main sections of the review are devoted to (i) analysis of the immune response to
H. pylori
in humans, (ii) analysis of interactions of
H. pylori
with host immune defenses in animal models, and (iii) interactions of
H. pylori
with immune cells in vitro. The topics addressed in this review are important for understanding how
H. pylori
resists immune clearance and also are relevant for understanding the pathogenesis of diseases caused by
H. pylori
(peptic ulcer disease, gastric adenocarcinoma, and gastric lymphoma).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology
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