Alteration of Fermentative Metabolism Enhances Mucor circinelloides Virulence-Reference-Cited by-同舟云学术

Alteration of Fermentative Metabolism Enhances Mucor circinelloides Virulence

Published:2020-01-22 Issue:2 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Díaz-Pérez Sharel P.¹,Patiño-Medina J. Alberto¹,Valle-Maldonado Marco I.¹,López-Torres Adolfo²,Jácome-Galarza Irvin E.³,Anaya-Martínez Verónica⁴,Gómez-Ruiz Verónica⁵,Campos-García Jesús¹,Nuñez-Anita Rosa E.⁶,Ortiz-Alvarado Rafael⁷,Ramírez-Díaz Martha I.¹,Gutiérrez-Corona J. Félix⁸,Meza-Carmen Víctor¹^ORCID

Affiliation:

1. Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo (UMSNH), Morelia, Michoacán, México

2. Universidad Papaloapan, Campus Tuxtepec, Tuxtepec, Oaxaca, México

3. Departamento de Biología Molecular, Laboratorio Estatal de Salud Pública del Estado de Michoacán, Morelia, Michoacán, México

4. Facultad de Ciencias de la Salud, Universidad Anáhuac, Huixquilucan, Estado de México, México

5. Laboratorio de Patología, Hospital Civil “Dr. Miguel Silva,” Morelia, Michoacán, México

6. Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás Hidalgo, Morelia, Michoacán, México

7. Facultad de Químico Farmacobiología, Universidad Michoacana de San Nicolás Hidalgo, Morelia, Michoacán, México

8. Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, Guanajuato, México

Abstract

The fungus Mucor circinelloides undergoes yeast-mold dimorphism, a developmental process associated with its capability as a human opportunistic pathogen. Dimorphism is strongly influenced by carbon metabolism, and hence the type of metabolism likely affects fungus virulence. We investigated the role of ethanol metabolism in M. circinelloides virulence.

Funder

Consejo Nacional de Ciencia y Tecnología

Universidad Michoacana de San Nicolás de Hidalgo

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00434-19

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