DNA Transport through the Dynamic Type IV Secretion System-Reference-Cited by-同舟云学术

DNA Transport through the Dynamic Type IV Secretion System

Published:2023-07-18 Issue:7 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ryan Mackenzie E.¹,Damke Prashant P.²,Shaffer Carrie L.¹²³⁴^ORCID

Affiliation:

1. Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, USA

2. Department of Veterinary Sciences, University of Kentucky College of Agriculture, Lexington, Kentucky, USA

3. Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA

4. Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA

Abstract

The versatile type IV secretion system (T4SS) nanomachine plays a pivotal role in bacterial pathogenesis and the propagation of antibiotic resistance determinants throughout microbial populations. In addition to paradigmatic DNA conjugation machineries, diverse T4SSs enable the delivery of multifarious effector proteins to target prokaryotic and eukaryotic cells, mediate DNA export and uptake from the extracellular milieu, and in rare examples, facilitate transkingdom DNA translocation.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00436-22

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