Peste Des Petits Ruminants Virus N Protein Is a Critical Proinflammation Factor That Promotes MyD88 and NLRP3 Complex Assembly-Reference-Cited by-同舟云学术

Peste Des Petits Ruminants Virus N Protein Is a Critical Proinflammation Factor That Promotes MyD88 and NLRP3 Complex Assembly

Published:2022-05-25 Issue:10 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Li Lingxia¹,Yang Wenping¹,Ma Xiaoxia²,Wu Jinyan¹,Qin Xiaodong¹,Cao Xiaoan¹,Zhou Jianhua²,Jin Li²,He Jijun¹,Zheng Haixue¹^ORCID,Liu Xiangtao¹,Li Dan¹^ORCID,Shang Youjun¹

Affiliation:

1. State Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, African swine fever Regional Laboratory of China, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China

2. Biomedical Research Center, Northwest Minzu University, Lanzhou, Gansu, China

Abstract

An important part of the innate immune response is the activation of NF-κB signaling pathway and NLPR3 inflammasome, which is induced upon exposure to pathogens. Peste des petits ruminants virus (PPRV) is a highly contagious virus causing fever, stomatitis, and pneumoenteritis in goats by inducing many proinflammatory cytokines.

Funder

Key R&D Plan Project of Ningxia Autonmous Region in 2021

State Key Laboratory of Veterinary Etiological Biology

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00309-22

Reference46 articles.

1. Peste des petits ruminants

2. Cytokines expression profile and kinetics of Peste des petits ruminants virus antigen and antibody in infected and vaccinated goats