Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2-Reference-Cited by-同舟云学术

Kinetic Characterization and Inhibitor Screening for the Proteases Leading to Identification of Drugs against SARS-CoV-2

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kuo Chih-Jung¹,Chao Tai-Ling²,Kao Han-Chieh²,Tsai Ya-Min²,Liu Yi-Kai¹,Wang Lily Hui-Ching³,Hsieh Ming-Chang⁴⁵,Chang Sui-Yuan²⁶,Liang Po-Huang⁷⁸^ORCID

Affiliation:

1. Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan

2. Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan

3. Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan

4. Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan

5. Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan

6. Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

7. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

8. Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan

Abstract

Coronavirus (CoV) disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has claimed many lives worldwide and is still spreading since December 2019. The 3C-like protease (3CL pro ) and papain-like protease (PL pro ) are essential for maturation of viral polyproteins in SARS-CoV-2 life cycle and thus regarded as key drug targets for the disease.

Funder

Ministry of Science and Technology, Taiwan

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02577-20

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