Integration of Human Immunodeficiency Virus Type 1 in Untreated Infection Occurs Preferentially within Genes-Reference-Cited by-同舟云学术

Integration of Human Immunodeficiency Virus Type 1 in Untreated Infection Occurs Preferentially within Genes

Published:2006-08 Issue:15 Volume:80 Page:7765-7768
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Liu Hongbing¹,Dow Eugene C.¹,Arora Reetakshi¹,Kimata Jason T.¹,Bull Lara M.²,Arduino Roberto C.²,Rice Andrew P.¹

Affiliation:

1. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas

2. Section of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at Houston School of Medicine, Houston, Texas

Abstract

ABSTRACT Previous analyses of human immunodeficiency virus type 1 (HIV-1) integration sites generated in infections in vitro or in patients in whom viral replication was repressed by antiviral therapy have demonstrated a preference for integration within protein-coding genes. We analyzed integration sites in peripheral blood mononuclear cells (PBMCs), spleen, lymph node, and cerebral cortex from patients with untreated HIV-1 infections. The great majority of integration sites in each tissue were within genes. Statistical analyses of the frequencies of integration in genes in PBMCs and lymph tissue demonstrated a strong preference for integration within genes. Although the sample size for brain tissue was too small to demonstrate a clear statistical preference for integration in genes, four of the five integration sites identified in brain were within genes. Taken together, our data indicate that HIV-1 preferentially integrates within genes during untreated infection.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00542-06

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