First Report of Ceftazidime-Avibactam Resistance in a KPC-3-Expressing Klebsiella pneumoniae Isolate-Reference-Cited by-同舟云学术

First Report of Ceftazidime-Avibactam Resistance in a KPC-3-Expressing Klebsiella pneumoniae Isolate

Published:2015-07-20 Issue:10 Volume:59 Page:6605-6607
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Humphries Romney M.,Yang Shangxin,Hemarajata Peera,Ward Kevin W.,Hindler Janet A.,Miller Shelley A.,Gregson Aric

Abstract

ABSTRACTCeftazidime-avibactam is the first antimicrobial approved by the U.S. FDA for the treatment of carbapenem-resistantEnterobacteriaceae. Avibactam, a non-β-lactam β-lactamase inhibitor, inactivates class A serine carbapenemases, includingKlebsiella pneumoniaecarbapenemase (KPC). We report a KPC-producingK. pneumoniaeisolate resistant to ceftazidime-avibactam (MIC, 32/4 μg/ml) from a patient with no prior treatment with ceftazidime-avibactam.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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