A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality-Reference-Cited by-同舟云学术

A Retrospective Controlled Cohort Study of the Impact of Glucocorticoid Treatment in SARS-CoV-2 Infection Mortality

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fernández-Cruz Ana¹^ORCID,Ruiz-Antorán Belén²,Muñoz-Gómez Ana³,Sancho-López Aránzazu²,Mills-Sánchez Patricia³,Centeno-Soto Gustavo Adolfo²,Blanco-Alonso Silvia³,Javaloyes-Garachana Laura²,Galán-Gómez Amy³,Valencia-Alijo Ángela³,Gómez-Irusta Javier³,Payares-Herrera Concepción²,Morrás-Torre Ignacio³,Sánchez-Chica Enrique³,Delgado-Téllez-de-Cepeda Laura⁴,Callejas-Díaz Alejandro¹,Ramos-Martínez Antonio¹⁴⁵^ORCID,Múñez-Rubio Elena¹,Avendaño-Solá Cristina²

Affiliation:

1. Infectious Diseases Unit, Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain

2. Clinical Pharmacology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain

3. Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain

4. Pharmacy Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain

5. Medicine Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain

Abstract

Evidence to support the use of steroids in coronavirus disease 2019 (COVID-19) pneumonia is lacking. We aim to determine the impact of steroid use for COVID-19 pneumonia on hospital mortality. We performed a single-center retrospective cohort study in a university hospital in Madrid, Spain, during March of 2020. To determine the role of steroids in in-hospital mortality, patients admitted with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia and treated with steroids were compared to patients not treated with steroids, and we adjusted with a propensity score for patients on steroid treatment.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01168-20

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