Complete Nucleotide Sequences of mcr-4.3 -Carrying Plasmids in Acinetobacter baumannii Sequence Type 345 of Human and Food Origin from the Czech Republic, the First Case in Europe

Author:

Bitar Ibrahim12,Medvecky Matej12,Gelbicova Tereza3,Jakubu Vladislav45,Hrabak Jaroslav2,Zemlickova Helena45ORCID,Karpiskova Renata3,Dolejska Monika16

Affiliation:

1. CEITEC VFU, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic

2. Faculty of Medicine, Biomedical Center, Charles University, Plzen, Czech Republic

3. Veterinary Research Institute, Brno, Czech Republic

4. National Reference Laboratory for Antibiotics, The National Institute of Public Health, Centre for Epidemiology and Microbiology, Prague, Czech Republic

5. Department of Clinical Microbiology, Faculty of Medicine and University Hospital, Charles University, Hradec Kralove, Czech Republic

6. Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic

Abstract

Here, we describe two plasmids carrying mcr-4.3 in two Acinetobacter baumannii strains isolated from imported food and a clinical sample. The comparative analysis of these plasmids, with two other plasmids reported in the NCBI database, highlighted the common origin of the plasmidic structure carrying mcr-4.3 . This is the first case of the mcr-4.3 gene in a A. baumannii strain isolated from a clinical case in Europe. We hypothesize that food import is initiating the spread in Czech Republic.

Funder

National Sustainability Program

Czech Health Research Council

Ministry of Agriculture of Czech Republic

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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