Tiny swabs: nasal swabs integrated into tube caps facilitate large-scale self-collected SARS-CoV-2 testing-Reference-Cited by-同舟云学术

Tiny swabs: nasal swabs integrated into tube caps facilitate large-scale self-collected SARS-CoV-2 testing

Published:2023-12-22 Issue: Volume: Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Pfau Brian¹,Opsahl Jordan¹,Crew Ruben¹,Best Sabrina¹,Han Peter D.¹,Heidl Sarah¹,McDermot Evan¹,Stone Jeremy¹,Schwabe-Fry Kristen¹,MacMillan Melissa P.²,O'Hanlon Jessica²,Sohlberg Sarah²,Acker Zack¹,Ehmen Brenna¹,Englund Janet A.¹³⁴,Konnick Eric Q.¹⁵,Chu Helen Y.¹²⁶⁷,Weil Ana A.¹⁶⁷⁸^ORCID,Lockwood Christina M.¹⁵⁹,Starita Lea M.¹⁹^ORCID,Bedford Trevor,Boeckh Michael,Chu Helen Y.,Englund Janet A.,Lockwood Christina M.,Lutz Barry R.,Prentice Robin,Shendure Jay,Starita Lea M.,Waghmere Alpana,Weil Ana A.,

Affiliation:

1. Brotman Baty Institute for Precision Medicine, Seattle, Washington, USA

2. Department of Medicine, University of Washington, Seattle, Washington, USA

3. Department of Pediatrics, University of Washington, Seattle, Washington, USA

4. Seattle Children’s Research Institute, Seattle, Washington, USA

5. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

6. Department of Epidemiology, University of Washington, Seattle, Washington, USA

7. Center for Emerging and Re-Emerging Infectious Diseases, University of Washington, Seattle, Washington, USA

8. Department of Global Health, University of Washington, Seattle, Washington, USA

9. Department of Genome Sciences, University of Washington, Seattle, Washington, USA

Abstract

ABSTRACT The COVID-19 pandemic spurred the development of innovative solutions for specimen collection and molecular detection for large-scale community testing. Among these developments is the RHINOstic nasal swab, a plastic anterior nares swab built into the cap of a standard matrix tube that facilitates automated processing of up to 96 specimens at a time. In a study of unsupervised self-collection utilizing these swabs, we demonstrate comparable analytic performance and shipping stability compared to traditional anterior nares swabs, as well as significant improvements in laboratory processing efficiency. The use of these swabs may allow laboratories to accommodate large numbers of sample collections during periods of high testing demand. Automation-friendly nasal swabs are an important tool for high-throughput processing of samples that may be adopted in response to future respiratory viral pandemics.

Funder

Gates Ventures

United States Senate and House of Representatives Bill 748, Coronavirus Aid, Relief and Economic Security Act

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.01285-23

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