Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates-Reference-Cited by-同舟云学术

Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates

Published:1996-07 Issue:7 Volume:64 Page:2824-2828
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Brett P J¹,Woods D E¹

Affiliation:

1. Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary Health Sciences Centre, Alberta, Canada.

Abstract

The O-polysaccharide moiety of Burkholderia pseudomallei 319a lipopolysaccharide was covalently linked to flagellin protein isolated from the same strain. A glycoconjugate incorporating adipic acid dihydrazide as a spacer molecule elicited high-titer immunoglobulin G responses to both the protein and carbohydrate components of the construct. This immunoglobulin G was capable of protecting diabetic rats from challenge with a heterologous B. pseudomallei strain.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.64.7.2824-2828.1996

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