Density Differences Between Hybrid and Nonhybrid Particles in Two Adenovirus-Simian Virus 40 Hybrid Populations

Author:

Baum Stephen G.12,Wiese William H.12,Rowe Wallace P.12

Affiliation:

1. Departments of Medicine and Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461

2. Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The adenovirus 7-simian virus 40 hybrid virus population E46 + was subjected to fixed-angle equilibrium density gradient centrifugation in CsCl. A difference in buoyant density between the hybrid virion and its nonhybrid adenovirus 7 counterpart was noted, the hybrid virion possessing the lower buoyant density. This difference in buoyant density appeared to be accentuated in a population of adenovirus 2 +t7 , a derivative of E46 + in which the adenovirus 7-simian virus 40 genome had been transferred to an adenovirus 2 capsid.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference18 articles.

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3. Possible incorporation of SV40 genome within capsid proteins of adenovirus 4;Easton J. M.;Proc. Nat. Acad. Sci. U.S.A.,1965

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5. Density gradient centrifugation of DNA in a fixed-angle rotor. A higher order of resolution;Flamm W. G.;Biochim. Biophys. Acta,1966

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Adenovirus-SV40 Hybrid Viruses;Comprehensive Virology Volume 13: Structure and Assembly;1979

2. Bibliography;The Biology of Animal Viruses;1974

3. Biological and biophysical characterization of SV 40 cytoplasmic T-antigen-inducing mutants of PARA-adenovirus 7;Archiv f�r die gesamte Virusforschung;1973-03

4. Components of Adenovirus-Simian Virus 40 Hybrid Viruses;Proceedings of the National Academy of Sciences;1971-07-01

5. Simian Virus 40 Integration Site in an Adenovirus 7-Simian Virus 40 Hybrid DNA Molecule;Proceedings of the National Academy of Sciences;1971-05-01

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