Long-Term Protective Immune Response Elicited by Vaccination with an Expression Genomic Library of Toxoplasma gondii-Reference-Cited by-同舟云学术

Long-Term Protective Immune Response Elicited by Vaccination with an Expression Genomic Library of Toxoplasma gondii

Published:2003-09 Issue:9 Volume:71 Page:5407-5411
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Fachado Alberto¹²,Rodriguez Alexandro²,Molina Judith³,Silvério Jaline C.¹,Marino Ana P. M. P.¹,Pinto Luzia M. O.¹,Angel Sergio O.⁴,Infante Juan F.⁵,Traub-Cseko Yara⁶,Amendoeira Regina R.⁷,Lannes-Vieira Joseli¹

Affiliation:

1. Laboratory of Autoimmunity and Immunoregulation, Department of Immunology

2. Laboratory of Molecular Biology, Department of Immunology, “Victoria de Giron” Medicine Institute

3. Department of Ultra-Structure and Cellular Biology

4. Laboratory of Molecular Biology, Department of Parasitology, “Carlos G. Malbran” Institute, Buenos Aires, Argentina

5. Department of Molecular Biology, “Carlos J. Finaly” Insitute, Havana, Cuba

6. Department of Biochemistry and Molecular Biology

7. Department of Protozoology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil

Abstract

ABSTRACT Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti- T. gondii DNA vaccine.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.9.5407-5411.2003

Reference35 articles.

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