Induction of L1 and L2 β-Lactamase Production in Stenotrophomonas maltophilia Is Dependent on an AmpR-Type Regulator-Reference-Cited by-同舟云学术

Induction of L1 and L2 β-Lactamase Production in Stenotrophomonas maltophilia Is Dependent on an AmpR-Type Regulator

Published:2008-04 Issue:4 Volume:52 Page:1525-1528
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Okazaki Aki¹,Avison Matthew B.¹

Affiliation:

1. Bristol Centre for Antimicrobial Research and Evaluation, Department of Cellular & Molecular Medicine, University of Bristol, Bristol, United Kingdom

Abstract

ABSTRACT A divergently oriented ampR has been located upstream of bla L2 in Stenotrophomonas maltophilia . AmpR is necessary for L1 and L2 β-lactamase induction in response to β-lactam challenge, and activation of AmpR is sufficient to induce L1 and L2 production. L1 induction requires more activation of AmpR than does L2 induction.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01485-07

Reference19 articles.

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5. Avison, M. B., C. J. von Heldreich, C. S. Higgins, P. M. Bennett, and T. R. Walsh. 2000. A TEM-2 β-lactamase encoded on an active Tn1-like transposon in the genome of a clinical isolate of Stenotrophomonas maltophilia. J. Antimicrob. Chemother.46:879-884.

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