Horizontal Transmissible Protection against Myxomatosis and Rabbit Hemorrhagic Disease by Using a Recombinant Myxoma Virus-Reference-Cited by-同舟云学术

Horizontal Transmissible Protection against Myxomatosis and Rabbit Hemorrhagic Disease by Using a Recombinant Myxoma Virus

Published:2000-02 Issue:3 Volume:74 Page:1114-1123
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bárcena Juan¹,Morales Mónica¹,Vázquez Belén¹,Boga José A.²,Parra Francisco²,Lucientes Javier³,Pagès-Manté Albert⁴,Sánchez-Vizcaíno José M.¹,Blasco Rafael¹,Torres Juan M.¹

Affiliation:

1. Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, 28130 Madrid,1

2. Departamento de Bioquı́mica y Biologı́a Molecular, Instituto Universitario de Biotecnologı́a de Asturias (CSIC), Universidad de Oviedo, 33006 Oviedo,2

3. Departamento de Patologı́a Animal, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza,3 and

4. Laboratorios Hipra S.A. Amer., 1710 Girona,4 Spain

Abstract

ABSTRACT We have developed a new strategy for immunization of wild rabbit populations against myxomatosis and rabbit hemorrhagic disease (RHD) that uses recombinant viruses based on a naturally attenuated field strain of myxoma virus (MV). The recombinant viruses expressed the RHDV major capsid protein (VP60) including a linear epitope tag from the transmissible gastroenteritis virus (TGEV) nucleoprotein. Following inoculation, the recombinant viruses induced specific antibody responses against MV, RHDV, and the TGEV tag. Immunization of wild rabbits by the subcutaneous and oral routes conferred protection against virulent RHDV and MV challenges. The recombinant viruses showed a limited horizontal transmission capacity, either by direct contact or in a flea-mediated process, promoting immunization of contact uninoculated animals.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.3.1114-1123.2000

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