Role of Complement in Immune Lysis of Trypanosoma cruzi-Reference-Cited by-同舟云学术

Role of Complement in Immune Lysis of Trypanosoma cruzi

Published:1972-11 Issue:5 Volume:6 Page:860-864
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Anziano Dante F.¹,Dalmasso Agustin P.¹,Lelchuk Rosalia¹,Vásquez César¹

Affiliation:

1. Institute of Medical Research and Institute of General Anatomy and Embryology, Faculty of Medicine, University of Buenos Aires, and Institute of Biology and Experimental Medicine, Buenos Aires, Argentina

Abstract

Studies were performed on the mechanism of immune lysis of culture forms of Trypanosoma (Schizotrypanum) cruzi. Antibody-mediated lysis is caused by complement, which is activated via the classical pathway. The properdin system is not required. The kinetics of the reaction is similar to that followed by immune lysis of sensitized sheep erythrocytes, as is the concentration of divalent cations required for optimal lysis (0.15 m m Ca 2+ and 0.5 m m Mg 2+ ), the occurrence of cell membrane uptake of the complement components C3 and C4, and the development of characteristic ultrastructural modifications on the cell membrane.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.6.5.860-864.1972

Reference23 articles.

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