Dissociation Between Ion Permeability and the Lethal Action of Polyene Antibiotics on Candida albicans-Reference-Cited by-同舟云学术

Dissociation Between Ion Permeability and the Lethal Action of Polyene Antibiotics on Candida albicans

Published:1978-06 Issue:6 Volume:13 Page:914-917
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chen Winston C.¹,Chou Dong-Lang¹,Feingold David S.¹

Affiliation:

1. Departments of Dermatology and Medicine, Boston University School of Medicine, and Boston Veterans Administration Hospital, Boston, Massachusetts 02130

Abstract

Kinetic data on potassium release from and killing of Candida albicans by the four polyene antibiotics amphotericin B, amphotericin B methyl ester hydrochloride, nystatin, and nystatin methyl ester hydrochloride are presented. The nystatins were relatively more effective than the amphotericins in causing potassium release rather than killing. These data suggest that the aqueous channels or pores formed by the polyene antibiotics are not central to the lethal action of the drugs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.13.6.914

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