Cephamycins, a New Family of β-Lactam Antibiotics I. Production by Actinomycetes, Including Streptomyces lactamdurans sp. n-Reference-Cited by-同舟云学术

Cephamycins, a New Family of β-Lactam Antibiotics I. Production by Actinomycetes, Including Streptomyces lactamdurans sp. n

Published:1972-09 Issue:3 Volume:2 Page:122-131
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Stapley E. O.¹²,Jackson M.¹²,Hernandez S.¹²,Zimmerman S. B.¹²,Currie S. A.¹²,Mochales S.¹²,Mata J. M.¹²,Woodruff H. B.¹²,Hendlin D.¹²

Affiliation:

1. Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065

2. Compania Espanola de la Penicilina y Antibioticos, S.A., Madrid, Spain

Abstract

A number of actinomycetes isolated from soil were found to produce one or more members of a new family of antibiotics, the cephamycins, which are structurally related to cephalosporin C. The cephamycins were produced in submerged fermentation in a wide variety of media by one or more of eight different species of Streptomyces , including a newly described species, S. lactamdurans . These antibiotics exhibit antibacterial activity against a broad spectrum of bacteria which includes many that are resistant to the cephalosporins and penicillins.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.2.3.122

Reference10 articles.

1. New j8-lactam antibiotics: structure determination of cephamycins A and B;Albers-Schonberg G.;Tetrahedron Lett.,1972

2. Microbial degradation of cephalosporin C;Demain A. L.;Nature (London),1963

3. Bacterial protoplasts induced by penicillin;Lederberg J.;Proc. Nat. Acad. Sci. U.S.A.,1956

4. Cephamycins, a new family of 6-lactam antibiotics. II. Isolation and chemical characterization;Miller T. W.;Antimicrob. Ag. Chemother.,1972

5. 5-Lactam antibiotics from Streptomyces;Nagarajan R.;J. Amer. Chem. Soc.,1971

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