Nucleo-Cytoplasmic Transport of ZIKV Non-Structural 3 Protein Is Mediated by Importin-α/β and Exportin CRM-1-Reference-Cited by-同舟云学术

Nucleo-Cytoplasmic Transport of ZIKV Non-Structural 3 Protein Is Mediated by Importin-α/β and Exportin CRM-1

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

De Jesús-González Luis Adrián¹²^ORCID,Palacios-Rápalo Selvin Noé¹^ORCID,Reyes-Ruiz José Manuel³⁴^ORCID,Osuna-Ramos Juan Fidel¹⁵^ORCID,Farfán-Morales Carlos Noe¹^ORCID,Cordero-Rivera Carlos Daniel¹^ORCID,Cisneros Bulmaro⁶^ORCID,Gutiérrez-Escolano Ana Lorena¹^ORCID,del Ángel Rosa María¹^ORCID

Affiliation:

1. Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies (CINVESTAV-IPN), Mexico City, Mexico

2. Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Atlixco, Mexico

3. Unidad Médica de Alta Especialidad, Hospital de Especialidades No. 14, Centro Médico Nacional “Adolfo Ruiz Cortines”, Instituto Mexicano del Seguro Social (IMSS), Veracruz, Mexico

4. Facultad de Medicina, Región Veracruz, Universidad Veracruzana, Veracruz, Mexico

5. Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico

6. Department of Genetics and Molecular Biology, Center of Research and Advanced Studies (CINVESTAV-IPN), Mexico City, Mexico

Abstract

Flaviviruses have a cytoplasmic replication cycle, but recent evidence indicates that nuclear elements play a role in their viral replication. Viral proteins, such as NS5 and C, are imported into the nucleus, and blocking their import prevents replication.

Funder

Consejo Nacional de Ciencia y Tecnología

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01773-22

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