Affiliation:
1. Department of Molecular Biology, Walter Reed Army Institute of Research, Washington, D.C. 20012, and Department of Microbiology, and University of Maryland, College Park, Maryland 20742
Abstract
The antibacterial drug Nitroakridin 3582 inhibited the growth of selected grampositive bacteria more strongly than it inhibited the growth of gram-negative bacilli. Nitroakridin at concentrations of the order of 5 × 10
−5
m
induced lysis of
Bacillus licheniformis
and
Micrococcus lysodeikticus
. At concentrations less than 10
−4
m
, Nitroakridin 3582 reduced the exponential growth rate of
Escherichia coli
C-2; at 10
−4
m
the drug was bacteriostatic, and, at concentrations greater than 10
−4
m
, it was bactericidal. Prolonged bacteriostasis resulted in the formation of long filaments by
E. coli, Serratia marcescens, Shigella sonnei
, and
Proteus mirabilis
. The reversible effects of Nitroakridin 3582 on the growth of
E. coli
correlated with partial inhibitions of deoxyribonucleic acid biosynthesis; ribonucleic acid and protein syntheses were inhibited less strongly. Nitroakridin 3582 at concentrations greater than 2 × 10
−4
m
, which block deoxyribonucleic acid biosynthesis, produced an accelerated bactericidal action.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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