The Antimalaria Drug Artesunate Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Activating AMPK and Nrf2/HO-1 Signaling Pathways

Author:

Long Feixiang1,Zhang Mingxin1,Yang Xia1,Liang Xiaohuan2,Su Lizhan1,An Tongqing3,Zhang Guihong2,Zeng Zhenling12,Liu Yahong12,Chen Weisan4,Chen Jianxin12ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China

2. Guangdong Laboratory for Lingnan Modern Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou, People's Republic of China

3. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

4. Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) infections have continuously threatened the pork industry worldwide. Vaccination strategies provide very limited protection against PRRSV infection, and no effective drug is commercially available.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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