Cross-Species Permissivity: Structure of a Goat Adeno-Associated Virus and Its Complex with the Human Receptor AAVR-Reference-Cited by-同舟云学术

Cross-Species Permissivity: Structure of a Goat Adeno-Associated Virus and Its Complex with the Human Receptor AAVR

Published:2022-12-21 Issue:24 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Large Edward E.¹^ORCID,Silveria Mark A.¹,Weerakoon Onellah¹,White Tommi A.¹,Chapman Michael S.¹^ORCID

Affiliation:

1. Department of Biochemistry, University of Missouri, Columbia, Missouri, USA

Abstract

Adeno-associated virus (AAV) is a small ssDNA satellite parvovirus. As a recombinant vector with a protein shell encapsidating a transgene, recombinant AAV (rAAV) is a leading delivery vehicle for gene therapy, with two FDA-approved treatments and 150 clinical trials for 30 diseases.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01484-22

Reference39 articles.

1. AAV: An Overview of Unanswered Questions

2. The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy

3. Biology of Adeno-associated Virus

4. Adeno-associated virus (AAV) cell entry: structural insights

5. Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry

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1. Structural basis of the recognition of adeno-associated virus by the neurological system-related receptor carbonic anhydrase IV;PLOS Pathogens;2024-02-05

2. Adeno-associated virus receptor complexes and implications for adeno-associated virus immune neutralization;Frontiers in Microbiology;2023-02-10

3. Cryo-EM structure of adeno-associated virus 4 at 2.2 Å resolution;Acta Crystallographica Section D Structural Biology;2023-01-20