Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms-Reference-Cited by-同舟云学术

Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms

Published:2021-05-18 Issue:6 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Butcher Mark C.¹,Brown Jason L.¹^ORCID,Hansom Donald¹²,Wilson-van Os Rebecca³,Delury Craig³,Laycock Phillip A.³,Ramage Gordon¹^ORCID

Affiliation:

1. Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

2. Forth Valley Royal Hospital, Larbert, United Kingdom

3. Biocomposites, Ltd., Keele, Staffordshire, United Kingdom

Abstract

Calcium sulfate (CS) has been used clinically as a bone- or void-filling biomaterial, and its resorptive properties have provided the prospect for its use as a release mechanism for local antibiotics to control biofilms. Here, we aimed to test CS beads loaded with three antifungal drugs against planktonic and sessile fungal species to assess whether these antifungal beads could be harnessed to provide consistent release of antifungals at biofilm-inhibitory doses.

Funder

Biocomposites

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02551-20

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