Enterovirus 71 Infection of Monocytes with Antibody-Dependent Enhancement-Reference-Cited by-同舟云学术

Enterovirus 71 Infection of Monocytes with Antibody-Dependent Enhancement

Published:2010-10 Issue:10 Volume:17 Page:1517-1523
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Wang Shih-Min¹²³,Chen I.-Chun¹²³,Su Ling-Yao¹²³,Huang Kao-Jean¹²³,Lei Huan-Yao¹²³,Liu Ching-Chuan¹²³

Affiliation:

1. Departments of Emergency Medicine

2. Pediatrics

3. Microbiology & Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Abstract

ABSTRACT Enterovirus (EV) is an RNA virus that has circulated with different serotypes and genotypes worldwide. Enterovirus 71 (EV71) is a major neurotropic virus that causes severe brain stem encephalitis (BE) in infants and young children. The most vulnerable age for fatal infection is 6 to 11 months. This is associated with the coincident decline in maternal antibodies. The current report describes our finding that EV71 can infect human peripheral blood monocytes. We were able to show that EV71 infection is enhanced in the monocytic cell line THP-1 by the presence of subneutralizing concentrations of anti-EV71 antibodies. We also found that antibody-dependent enhancement (ADE) is mediated in part by Fcγ receptors. These observations support the concept that ADE augments the infectivity of EV71 for human monocytes and contributes to the age-dependent pathogenesis of EV71-induced disease. The ADE phenomenon must be considered during the development of an EV71 vaccine.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00108-10

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