Affiliation:
1. Division of Molecular Virology and Immunology, Georgetown University, Rockville, Maryland, USA.
Abstract
Penciclovir [9-(4-hydroxy-3-hydroxymethylbut-1-yI)guanine], an effective antiherpesvirus agent, was found to be a potent and selective antiviral agent against intracellular hepatitis B virus (HBV) replication (drug concentration at which a 10-fold decrease in HBV DNA from the average level in an untreated culture was observed [EC90], 1.6 microM) and extracellular virion release (EC90, 0.7 microM) by cultured human hepatoblastoma (2.2.15) cells. Acyclovir and three other related 9-alkoxypurines with activity against either herpesviruses or human immunodeficiency virus were uniformly inactive against HBV. The activity of penciclovir is discussed in relation to recent findings related to its mode of action against HBV.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference26 articles.
1. Controlled clinical trial of acyclovir in chronic hepatitis B virus infection;Alexander G. J. M.;J. Med. Virol.,1987
2. Penciclovir: a review of its spectrum of activity, selectivity and cross-resistance pattern;Boyd M. R.;Antiviral Chem. Chemother.,1993
3. .Darlison S. J. D. L. Earnshaw and R. A. Vere Hodge. Personal communication.
4. Double-blind, randomized, three-month, dose-ranging trial of lamivudine for chronic hepatitis B;Dienstag J. L.;J. Hepatol.,1994
5. Antiviral 9-[2-(phosphonomethoxy)alkoxy]purines;Duckworth D. M.;Antiviral Chem. Chemother.,1991
Cited by
81 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献