Kill kinetics and regrowth patterns of Pseudomonas aeruginosa exposed to concentration-time profiles of tobramycin simulating in vivo infusion and bolus dosing-Reference-Cited by-同舟云学术

Kill kinetics and regrowth patterns of Pseudomonas aeruginosa exposed to concentration-time profiles of tobramycin simulating in vivo infusion and bolus dosing

Published:1996-05 Issue:5 Volume:40 Page:1321-1324
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wood P J¹,Ioannides-Demos L L¹,Bastone E B¹,Spicer W J¹,McLean A J¹

Affiliation:

1. Department of Clinical Pharmacology, Monash University Department of Microbiology, Prahran, Victoria, Australia.

Abstract

Pseudomonas aeruginosa ATCC 27853 was exposed to tobramycin concentration-time profiles modelling in vivo bolus and infusion dosing. Dependence of bactericidal and bacteriostatic activity on the initial profile of peak concentration (bolus effect > infusion) and area under the antibiotic concentration-time curve was observed at peak concentration/MIC ratios of 10 or below.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.40.5.1321

Reference27 articles.

1. What is the evidence for once-daily aminoglycoside therapy;Barclay M. L.;Clin. Pharmacokinet.,1994

2. Kill kinetics and regrowth patterns of Escherichia coli exposed to gentamicin concentration-time profiles simulating in vivo bolus and infusion dosing;Bastone E. B.;Antimicrob. Agents Chemother.,1993

3. Evidence that amikacin ototoxicity is related to total perilymph area under the concentration-time curve regardless of concentration;Beaubien A. R.;Antimicrob. Agents Chemother.,1991

4. Gibaldi M. and D. Perrier. 1982. Pharmacokinetics 2nd ed. p. 445-449. Marcel Dekker Inc. New York.

5. Single daily ceftriaxone and tobramycin in the empirical management of febrile neutropenic patients: a randomised trial;Gibson J.;Int. J. Hematol.,1993

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Initial Concentration-Time Profile of Gentamicin Determines Efficacy against Enterobacter cloacae ATCC 13047;Antimicrobial Agents and Chemotherapy;1998-06

2. Changes in MIC Alter Responses of Pseudomonas aeruginosa to Tobramycin Exposure;Antimicrobial Agents and Chemotherapy;1998-06