Molecular Characterization of Mycoplasma pneumoniae Isolates in the United States from 2012 to 2018

Author:

Xiao L.1ORCID,Ratliff A. E.2,Crabb D. M.2,Mixon E.3,Qin X.4,Selvarangan R.5,Tang Y.-W.6,Zheng X.7ORCID,Dien Bard J.8ORCID,Hong T.9,Prichard M.3,Brooks E.10,Dallas S.11,Duffy L. B.2,Fowler K. B.3,Atkinson T. P.3,Waites K. B.2ORCID

Affiliation:

1. Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

2. Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA

3. Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA

4. Department of Laboratory Medicine and Pathology, Seattle Children’s Hospital, Seattle, Washington, USA

5. Children’s Mercy Hospital, Kansas City, Missouri, USA

6. Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, New York, USA

7. Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, USA

8. Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

9. Department of Pathology, Hackensack University Medical Center, Hackensack, New Jersey, USA

10. Departments of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA

11. Departments of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA

Abstract

Mycoplasma pneumoniae is a major cause of community-acquired pneumonia. There are limited data in the United States on the molecular epidemiological characteristics of M. pneumoniae . We collected 446 M. pneumoniae -positive specimens from 9 states between August 2012 and October 2018. Culture, antimicrobial susceptibility testing, P1 subtyping, and multilocus VNTR (variable-number tandem repeats) analysis (MLVA) were performed to characterize the isolates.

Funder

HHS | NIH | National Cancer Institute

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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